Senior Medical Science Liaison

About Xenon Pharmaceuticals Inc.

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We foster a respectful, collaborative, inclusive, and productive culture, inviting talented individuals to join our team.

What We Do

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy and depression. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. Building upon the positive results and compelling data from our Phase 2b X-TOLE study in adult patients with focal epilepsy, our Phase 3 epilepsy program includes multiple clinical trials evaluating azetukalner in patients with focal onset seizures and primary generalized tonic-clonic seizures. We anticipate topline data from our Phase 3 X-TOLE2 study in March 2026. Additionally, we have multiple Phase 3 azetukalner clinical trials underway for major depressive disorder (MDD) and bipolar depression (BPD), based on positive Phase 2 X-NOVA data. Our discovery labs are also driving leading-edge science, leveraging extensive ion channel expertise to identify validated drug targets and develop new product candidates. We've initiated Phase 1 studies for our follow-on Kv7 channel opener, XEN1120, and our lead Nav1.7 development candidate, XEN1701, in pain. Backed by a strong balance sheet, we are building a fully integrated, premier neuroscience company with robust discovery, clinical development, corporate, and commercial operations.

About The Senior Medical Science Liaison Role

Xenon Pharmaceuticals Inc. is seeking a Senior Medical Science Liaison for a field-facing role, instrumental in shaping and advancing the MSL function. This position supports Medical Affairs and Clinical Development teams by engaging external Healthcare Providers (HCPs), Key Opinion Leaders (KOLs), and patient groups. The primary objective is to provide education on Xenon's pipeline in epilepsy.

Reporting to the Regional Senior Director, Field Based Medicine, this Senior Medical Science Liaison will be responsible for the Northwest Region, encompassing Northern California, Washington, Oregon, Utah, Idaho, Montana, Wyoming, and Alaska. Preference is for the selected individual to reside in the San Francisco or Seattle area.

The ideal candidate is a clinical or scientific professional possessing a profound passion for science, deep scientific knowledge, and a proven ability to communicate complex medical information clearly. This role requires an individual who actively seeks to understand the needs of healthcare providers, patients, and families, and collaborates effectively to solve critical scientific and business challenges.

Key Responsibilities

• Identify, develop, and maintain valued scientific relationships with key external stakeholders including KOLs, HCPs, payors, academic and healthcare institutions, and advocacy groups.
• Act as a primary scientific resource, communicating up-to-date medical, clinical, and scientific information about Xenon’s neurology and epilepsy products and pipeline.
• Advance Xenon’s scientific platform and medical information, ensuring alignment with corporate and medical objectives.
• Engage in projects and initiatives aligned to medical strategies, adapting plans and tactics for the assigned territory.
• Identify and report timely and relevant scientific/clinical insights, trends, opportunities, and threats for targeted products.
• Collaborate with internal clinical development teams to enhance patient enrollment in Xenon-sponsored clinical trials, including investigator identification for epilepsy programs.
• Respond to and accurately document unsolicited requests for scientific information.
• Lead assigned national and/or regional congress activities in accordance with Medical Affairs strategies.
• Provide instruction, coaching, and mentoring to new or less experienced MSLs.
• Travel domestically up to 50% of the time, including overnight travel, with potential ad-hoc international travel.
• Ensure all activities adhere to Company policies, including the Code of Business Conduct and Ethics.

Qualifications

• Minimum of a relevant doctorate degree (M.D., PhD, PharmD, DPH, DNP).
• Minimum 5 years of relevant MSL experience required; 8+ years strongly preferred.
• Experience in neurology therapeutic area or epilepsy is required.
• Established relationships with KOLs and knowledge of institutions in neurology; epilepsy strongly preferred.
• Clinical trial development and drug launch experience are strongly preferred.
• Ability to communicate accurately, concisely, credibly, and confidently; adept at understanding other viewpoints and adjusting communication appropriately.
• Proven ability to deliver reliably against goals, work independently and cross-functionally, and demonstrate an aptitude for learning.
• Strong knowledge of clinical research processes, FDA regulations, and OIG guidelines required.

Our Culture & Benefits

Xenon offers a comprehensive Total Rewards program including base salary, target bonus, and stock options. Our full range of benefits covers medical, dental, vision, short- & long-term disability, accidental death & dismemberment, life insurance programs, Employee Assistance Program, and travel insurance. We also provide retirement savings programs with company matching contributions.

We encourage work-life balance through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development, offering an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

Key skills/competency

• Medical Science Liaison
• Neurology
• Epilepsy
• KOL Engagement
• Scientific Communication
• Clinical Development
• FDA Regulations
• PharmD/PhD/MD
• Market Access
• Therapeutic Area Expertise