Scientist, In Vivo CAR-T

@ Legend Biotech US

Overview

Legend Biotech is a global biotechnology company dedicated to treating life-threatening diseases. Based in Piscataway, NJ, the Scientist, In Vivo CAR-T role is part of the Research & Early Development team. You will contribute to advancing pipeline programs by developing next-generation cell therapies using in vivo gene delivery technologies and designing novel CAR constructs.

Key Responsibilities

• Work independently under minimal supervision.
• Conduct functional characterization of T cells transduced with in vivo CAR viruses using cytotoxicity, serial cytotoxicity, and cytokine release assays.
• Develop cell and gene therapy platforms including vector design, virus packaging, titering, immune cell isolation, expansion, multi-color flow cytometry, ELISA, cytotoxic assays, and VCN analysis.
• Plan experiments to generate reliable, consistent data.
• Analyze and present data in internal meetings and other forums.
• Dissect published literature for novel solutions to in-vivo cell therapy challenges.
• Generate, manage, and maintain critical data in an organized manner.

Requirements

The ideal candidate will have a Master in Biology, oncology, immunology or related discipline with 2+ years of experience in cell therapy. Prior knowledge of T cell culture methods, flow cytometry, qPCR/ddPCR assays, transfection, lentivirus or retrovirus transduction, and in vivo CAR virus evaluation is preferred. Strong problem-solving skills and independent planning ability are essential.

Benefits & Work Culture

A comprehensive benefits package includes medical, dental, vision, 401(k) with company match, equity options, paid parental leave, vacation, and additional perks. Legend Biotech fosters a diverse, inclusive, and supportive work environment.

Key skills/competency

Scientist, In Vivo CAR-T, cell therapy, immunotherapy, gene delivery, CAR constructs, T cell assays, flow cytometry, qPCR, regulatory compliance