Senior Bioinformatics Scientist

@ Karius

About Karius

Karius is a life science, venture-backed clinical metagenomics company focused on elevating patient care through microbial insights. We advance diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases utilizing genomics and AI.

Why Should You Join Us?

Karius' mission is to conquer infectious diseases with innovations around genomic sequencing and machine learning. The platform delivers unprecedented insight by detecting microbial cell-free DNA from blood, opening valued opportunities beyond diagnosing infections.

Position Summary

As a Senior Bioinformatics Scientist at Karius, you will join the Computational Biomarker Discovery team, analyzing complex biological data to unlock signatures for precision medicine beyond infectious diseases, including autoimmune disorders and oncology. You will design analysis plans, develop computational workflows, and integrate biological rationale with data-driven insights under the direction of the Director, Computational Biomarker Discovery.

Primary Responsibilities

• Lead data analysis of complex biological datasets including NGS, metagenomics, transcriptomics, fragmentomics, and single-cell analysis.
• Create or adapt computational tools and algorithms to support biomarker discovery.
• Drive bioinformatics aspects of cross-functional research projects in close collaboration with scientific and medical leaders.
• Conduct deep exploration of the interplay between molecular data and disease conditions.
• Deliver preliminary biological signatures to inform translational science and precision medicine.
• Partner in experimental design, methodology selection, and computational analysis.
• Collaborate with multi-disciplinary teams to support new partnerships and products.
• Ensure data integrity, quality control and rigorous documentation.
• Communicate progress and results to stakeholders on a weekly basis.
• Continuously grow knowledge in biological sciences and emerging technologies.

What’s Fun About the Job?

Work at the edge of innovation in infectious disease diagnostics, utilizing advanced technologies to make a tangible impact on patient care.

Travel & Physical Requirements

Remote employees travel quarterly to HQ. Work is primarily office-based, requiring periods of sitting/standing with moderate noise levels.

Position Requirements

• Ph.D. (or Master’s with sufficient industry experience) in a related field.
• Publications demonstrating innovative computational models.
• Strong background in modern statistics, machine learning and analysis of high-dimensional datasets.
• Excellent communication and collaboration skills.
• Proficiency in bioinformatics tools, particularly NGS data analysis.
• Familiarity with exploratory study and clinical trial design and analyses.

Personal Qualifications

• Passionate and purpose-driven.
• Detail oriented with exceptional time management skills.
• Self-starter able to drive results in a fast-paced startup environment.

Disclaimer

This job description outlines the general nature and level of work expected. Responsibilities may change at the discretion of Karius.

Equal Opportunity Employer

Karius values diversity and provides equal employment opportunities. Applicants with disabilities are invited to apply and may request accommodations by contacting recruiting@kariusdx.com.

Key skills/competency

• Bioinformatics
• NGS Analysis
• Metagenomics
• Machine Learning
• Statistical Analysis
• Data Integrity
• Translational Science
• Algorithm Development
• Computational Workflows
• Precision Medicine