Scientist, Computational Biology
@ Flagship Pioneering, Inc.

Cambridge, Massachusetts, United States
On Site
Posted 19 days ago

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Job Details

About Vesalius Therapeutics

Vesalius Therapeutics is pioneering a revolutionary platform to generate breakthrough treatments for common diseases. The platform uses large-scale human genetics, genomics, stem cell studies and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies.

Founded in 2019 by Flagship Pioneering, Vesalius enables smaller, shorter clinical trials with a higher probability of success. For more information visit vesaliustx.com or follow them on X and LinkedIn.

The Role

Vesalius Therapeutics is seeking a Scientist, Computational Biology with expertise in Bayesian inference, network analysis (structure learning, counterfactual inference), and/or sequence modeling (sgRNA design, mutation/selection, prediction). Reporting to the Head of Data Science, you will apply or develop state-of-the-art computational methods to deliver biological insights by integrating internal and external data sets.

Your role includes developing scalable, reproducible scientific code (demonstrated by a public Github repository) and applying a solid foundation in applied statistics and biology. As part of a matrixed team that includes wet lab scientists, statistical geneticists, and machine learning scientists, you will help to redefine common diseases and develop new therapeutics.

What You’ll Do

  • Deliver insights into cellular networks, patient biomarkers, and in-vitro models.
  • Identify relevant external data sets and internal data opportunities.
  • Write and deploy high-performance code and pipelines for large-scale computation.
  • Communicate clearly with both technical and non-technical audiences.

What You’ll Bring

  • PhD in Computer Science, Computational Biology, Biostatistics, Physics, Mathematics, Statistics, or related field.
  • Proficiency in a programming language such as Python or R, supported by a public Github repository.
  • Experience in developing novel models, algorithms, or software implementations is a plus.
  • Strong communication skills in writing and speaking.

Key skills/competency

  • Computational Biology
  • Bayesian Inference
  • Network Analysis
  • Sequence Modeling
  • High-Performance Computing
  • Python
  • R
  • Applied Statistics
  • Data Science
  • Biological Insights

How to Get Hired at Flagship Pioneering, Inc.

🎯 Tips for Getting Hired

  • Customize your resume: Highlight computational biology and coding skills.
  • Showcase your portfolio: Include your public Github contributions.
  • Research Vesalius: Understand their platform and methodology.
  • Practice technical interviews: Focus on algorithms and statistical models.

📝 Interview Preparation Advice

Technical Preparation

Review Bayesian statistical methods and applications.
Practice coding in Python and R.
Study network analysis and sequence modeling techniques.
Update your public Github repository with projects.

Behavioral Questions

Describe teamwork in cross-functional projects.
Explain handling project challenges effectively.
Share experience communicating complex ideas.
Discuss time management in research tasks.

Frequently Asked Questions