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Sr. Scientist, Bioanalytical CRO Management, DMPK - Orexin Programs
Centessa Pharmaceuticals
Original Job Summary
Overview
Centessa Pharmaceuticals is a new kind of pharmaceutical company that prioritizes data driven decision making led by subject matter experts. They are advancing a portfolio of high conviction programs through an asset-centric model that emphasizes speed, quality, and modest costs.
Position Summary
The Sr. Scientist, Bioanalytical CRO Management, DMPK - Orexin Programs partners with CROs to develop, qualify, and validate bioanalytical methods for quantifying small molecule drugs and metabolites in biological matrices. This role supports both preclinical and clinical studies and requires expertise in analytical chemistry and quantitative LC-MS/MS method development.
Key Responsibilities
- Manage and collaborate with CROs for method transfer and sample analysis.
- Review statements of work to ensure project alignment.
- Analyze bioanalytical data and review validation reports.
- Coordinate compound shipments and track study deliverables.
- Ensure compliance with GLP, FDA, EMA and other regulatory guidelines.
- Write SOPs and document key decisions.
- Represent DMPK in cross-functional project meetings.
Requirements
- Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field.
- Minimum 4 years of biotech/pharmaceutical industry experience.
- Experience managing CROs and external assay transfers.
- Hands-on LC-MS/MS method development experience.
- Proficiency with LC-MS/MS instruments and software (Sciex, Waters, Thermo).
- Familiarity with IND-enabling studies and regulatory guidelines.
Work Location
This is a fully remote position open to candidates based in the United States or the United Kingdom, with infrequent travel (approximately 10%) to the Boston, MA headquarters.
Key skills/competency
- CRO management
- bioanalytical methods
- mass spectrometry
- LC-MS/MS
- regulatory compliance
- analytical chemistry
- data integrity
- SOP writing
- FDA guidelines
- GLP
How to Get Hired at Centessa Pharmaceuticals
🎯 Tips for Getting Hired
- Research Centessa Pharmaceuticals: Understand their asset-centric R&D model and mission.
- Customize your resume: Highlight CRO management and LC-MS/MS expertise.
- Showcase regulatory know-how: Emphasize FDA, EMA, and GLP experience.
- Prepare detailed examples: Illustrate past analytical and problem-solving projects.