Manager, Clinical Pharmacology & Pharmacometrics
BeOne Medicines · United States
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- Hybrid
- Full-time
- $160,100 / year
- United States
Job highlights
- Support clinical pharmacology activities for novel drug assets.
- Perform non-compartmental analysis and data visualization.
- Ensure data integrity through quality control processes.
- Utilize R and Phoenix WinNonlin for data analysis.
- Collaborate with experienced professionals in a growing company.
About the role
Manager, Clinical Pharmacology & Pharmacometrics
BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.
General Description
We are seeking a highly motivated candidate to join our Clinical Pharmacology and Pharmacometrics (CPP) group. The successful candidate will support a variety of Clinical Pharmacology activities, including tasks related to non-compartmental analysis (NCA), data visualization, table generation, quality control (QC) of results, and data curation to support novel small molecules and biologics assets in the company portfolio. This role requires a strong STEM background and proficiency in data manipulation tools such as R and/or Phoenix WinNonlin (WNL). Exposure to clinical pharmacology and pharmacometric approaches for characterizing pharmacokinetic profiles; assessing drug/food interaction potential; characterizing QT prolongation potential, etc is desirable but not required.
Essential Functions Of The Job
You will work with experienced colleagues in the CPP group on facilitating the following activities to support Exploratory Analyses, CSRs, Health Authority responses, or Marketing authorization/NDA/BLA submissions:
- Non-Compartmental Analysis (NCA): Perform NCA to characterize the pharmacokinetics of drug candidates. Interpret and report NCA results.
- Data Visualization and Table Generation: Create visualizations and tables to effectively communicate pharmacokinetic and pharmacodynamic data. Ensure accuracy and clarity in data presentation.
- Quality Control (QC) of Results: Perform QC checks on analysis results to ensure data integrity and compliance with internal and regulatory standards. Document QC processes and findings.
- Data Curation and Engineering: Modify large datasets to prepare for analysis. Utilize tools such as R and Phoenix WinNonlin to streamline workflows. Support assembly of relevant ClinPharm datasets.
Supervisory Responsibilities
Assist with and/or lead internal trainings periodically
Computer Skills
- Proficiency in using R for data manipulation, visualization, and basic statistical analyses is required.
- Hands-on experience in performing NCA using Phoenix WinNonlin is preferred.
- Experience or exposure with one or more of the following is desirable: NONMEM, Berkeley Madonna, Simcyp, Gastroplus, Matlab.
- Exposure to working with and manipulating large datasets
Education Required
A B.S. with 5+ years relevant work experience, a M.S. with 4+ years relevant work experience, or PhD with 2+ years relevant work experience. Education: Pharmacokinetics, Pharmaceutical Sciences/Pharmacy, Biomedical Engineering, Bioinformatics, Data Sciences, Mathematics, or related STEM discipline.
Other Qualifications
- Demonstrated commitment to problem solving and developing creative solutions
- Detail oriented to ensure accuracy and thoroughness of work
- Ability to multi-task
- Ability to adapt to fast-moving timelines and quick turnaround times
- Strong written and oral communication skills
- Strong drive to learn and apply emerging technologies such as AI, ML, or other tools to improve daily task efficiencies
Travel: N/A
Global Competencies
When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.
- Fosters Teamwork
- Provides and Solicits Honest and Actionable Feedback
- Self-Awareness
- Acts Inclusively
- Demonstrates Initiative
- Entrepreneurial Mindset
- Continuous Learning
- Embraces Change
- Results-Oriented
- Analytical Thinking/Data Analysis
- Financial Excellence
- Communicates with Clarity
Key skills/competency
- Clinical Pharmacology
- Pharmacometrics
- Non-Compartmental Analysis (NCA)
- Data Visualization
- R Programming
- Phoenix WinNonlin
- Data Curation
- Quality Control (QC)
- Pharmacokinetics
- STEM
Skills & topics
- Manager
- Clinical Pharmacology
- Pharmacometrics
- Non-Compartmental Analysis
- NCA
- Data Visualization
- R
- Phoenix WinNonlin
- Pharmacokinetics
- Data Curation
- Quality Control
- STEM
- Biotechnology
- Pharmaceutical
- Drug Development
How to get hired
- Tailor your resume: Highlight your STEM background, R and Phoenix WinNonlin proficiency, and any clinical pharmacology experience.
- Showcase problem-solving: Emphasize your detail-oriented approach and creative solutions in your application.
- Prepare for technical questions: Be ready to discuss your experience with NCA, data visualization, and data curation tools.
- Demonstrate collaboration: Mention your ability to work effectively in a team and contribute to training.
- Research BeOne Medicines: Understand their mission to fight cancer and their commitment to innovation.
Technical preparation
Behavioral questions
Frequently asked questions
- What are the key technical skills for the Manager, Clinical Pharmacology & Pharmacometrics role at BeOne Medicines?
- The Manager, Clinical Pharmacology & Pharmacometrics role at BeOne Medicines requires proficiency in R for data manipulation and visualization, and hands-on experience with Phoenix WinNonlin for Non-Compartmental Analysis (NCA). Experience with other tools like NONMEM, Berkeley Madonna, Simcyp, Gastroplus, or Matlab is also desirable.
- What kind of educational background is preferred for this position at BeOne Medicines?
- BeOne Medicines prefers candidates with a strong STEM background. This includes degrees in Pharmacokinetics, Pharmaceutical Sciences/Pharmacy, Biomedical Engineering, Bioinformatics, Data Sciences, Mathematics, or related fields. The required experience varies with the degree level (B.S. 5+ years, M.S. 4+ years, PhD 2+ years).
- How important is experience with data manipulation and analysis tools for this role?
- Experience with data manipulation and analysis tools is crucial. Proficiency in R is required, and hands-on experience with Phoenix WinNonlin is preferred. The ability to work with and manipulate large datasets is also emphasized for this Manager, Clinical Pharmacology & Pharmacometrics position.
- What are the primary responsibilities of the Manager, Clinical Pharmacology & Pharmacometrics at BeOne Medicines?
- The primary responsibilities include performing Non-Compartmental Analysis (NCA), generating data visualizations and tables, conducting quality control (QC) on analysis results, and curating data to support drug development. You will also assist with or lead internal training sessions.
- Does BeOne Medicines offer opportunities for professional growth in emerging technologies for this role?
- Yes, BeOne Medicines encourages employees to apply emerging technologies such as AI and ML to improve daily task efficiencies. This demonstrates a commitment to continuous learning and leveraging new tools within the Clinical Pharmacology and Pharmacometrics group.
- What is the salary range for the Manager, Clinical Pharmacology & Pharmacometrics position at BeOne Medicines?
- The listed salary range for the Manager, Clinical Pharmacology & Pharmacometrics position at BeOne Medicines is $120,100.00 - $160,100.00 annually, not including potential bonuses or equity.