Principal Scientist, Research Computational Biology

Amgen: Serving Patients Through Scientific Innovation

At Amgen, you’re part of something bigger – a shared mission to serve patients living with serious illnesses. Since 1980, Amgen has pioneered biotech in the fight against tough diseases, focusing on Oncology, Inflammation, General Medicine, and Rare Disease. As a member of the Amgen team, you’ll make a lasting impact, researching, manufacturing, and delivering innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges, you’ll thrive at Amgen, transforming patient lives while transforming your career.

About the Principal Scientist, Research Computational Biology Role

The ARIA Computational Biology team at Amgen is seeking a talented and creative computational biologist. In this role, you will apply your expertise in data science and disease biology to accelerate the identification, prioritization, and validation of transformative therapeutic targets in a dynamic cross-functional research environment. Your scientific and technical leadership will shape computational biology strategy across multiple discovery programs, influencing target selection, biomarker strategy, and translational hypotheses.

What You Will Do

• Drive the extraction of biological insight from complex multi-modal omics and screening data to characterize disease endotypes and mechanisms.
• Identify novel targets and biomarkers, and test therapeutic hypotheses.
• Develop and leverage methods/platforms to discover, prioritize, and validate targets across diverse diseases and therapeutic modalities.
• Conduct innovative research in close partnership with Amgen therapeutic area scientists, spanning both internal pipeline programs and external partnerships.
• Shape roadmap priorities with data science and information systems teams to incorporate tools and analyses developed within ARIA Computational Biology into integrated R&D platforms.

What We Expect Of You

We seek a dynamic professional with the following qualifications:

Basic Qualifications:

• Doctorate in computational biology, bioinformatics, data science, or a related discipline (and relevant post-doc where applicable) and 2 years of computational biology experience.
• Or Master’s degree and 5 years of computational biology experience.
• Or Bachelor’s degree and 7 years of computational biology experience.

Preferred Qualifications:

• Strong research background in cardiometabolic disease and/or immunology, including mechanistic characterization using multi-modal single-cell data.
• Proven track record of driving programs or platforms that materially impacted discovery or early development decisions.
• Experience mentoring scientists and setting standards for computational best practices within a team.
• Ability to integrate portfolio-level business context into research strategy.
• Strong programming skills (Python, R, Linux/Unix), familiarity with cloud computing environments, HPC, and collaborative coding practices (e.g., Git).
• Track record of designing and implementing creative and holistic computational strategies to address challenging research questions.
• Demonstrated expertise in the analysis and interpretation of single cell omics data.
• Excellent presentation and communication skills to convey complex findings to diverse audiences.
• Experience leveraging and fine-tuning transcriptional foundation models, LLMs, and biomedical knowledge graphs to further research goals.
• Familiarity with public data resources (e.g., DepMap, Human Cell Atlas, TCGA, GTEx, and Tahoe-100M) frequently used to augment analyses of internally generated data.
• Experience developing and deploying tools and pipelines to endpoints such as interactive portals (e.g., RShiny, Streamlit), workflow management systems (e.g., Nextflow), and agentic frameworks.

What You Can Expect From Us

Amgen cares for your professional and personal growth and well-being. From competitive benefits to a collaborative culture, we support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted, with actual salary varying based on skills, experience, and qualifications.

Amgen offers a Total Rewards Plan, based on eligibility, comprising:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models, including remote and hybrid work arrangements, where possible.

Amgen fosters an inclusive environment of diverse, ethical, committed, and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.

Key skills/competency

• Computational Biology
• Omics Data Analysis
• Target Identification
• Biomarker Strategy
• Data Science
• Single-Cell Analysis
• Python/R Programming
• Cloud Computing
• Machine Learning
• Scientific Leadership