Observational Research Senior Manager Obesity

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Join Amgen’s Mission of Serving Patients. At Amgen, you'll be part of something bigger, driven by a shared mission to serve patients living with serious illnesses. Since 1980, Amgen has pioneered biotech, fighting tough diseases in Oncology, Inflammation, General Medicine, and Rare Disease, reaching millions of patients annually. As part of the Amgen team, you'll make a lasting impact on patients' lives by researching, manufacturing, and delivering innovative medicines for longer, fuller, happier lives.

Our award-winning culture is collaborative, innovative, and science-based. Thrive at Amgen if you have a passion for challenges and opportunities. Transform patients' lives and your career with us.

Observational Research Senior Manager Role Overview

Amgen is seeking an Observational Research Senior Manager (Epidemiology) focused on the obesity therapeutic area. This role supports pharmacovigilance epidemiology and causal inference teams, generating real-world evidence for various business needs. Observational research (OR) is crucial in drug development and commercialization, with increasing demand from regulatory and reimbursement authorities. The Center for Observational Research (CfOR) generates real-world evidence across the product lifecycle, covering disease frequency, burden, natural history, clinical trial design, treatment costs, utilization, and safety/effectiveness of interventions.

Reporting to the lead for the Pharmacovigilance Epidemiology and Causal Inference team in the Data and Analytics Center (DAC), this Senior Manager will be a recognized scientific contributor, authoring peer-reviewed papers, abstracts, or internal reports. This position can be based at Amgen's Thousand Oaks headquarters or be remote.

Key Activities

• Design and execute studies using causal inference frameworks to generate evidence for patient populations, disease burden, resource utilization, product registrations, label expansions, post-marketing requirements, and product differentiation.
• Identify opportunities to substitute or complement interventional studies to reduce drug development time and cost.
• Influence cross-functional stakeholders on the appropriate use and timing of non-interventional research for strategic business questions.
• Leverage real-world data and CfOR analytic approaches to inform high-value business decisions for multiple stakeholders.
• Contribute to CfOR's mission by advancing innovative epidemiological methods and analytical capabilities, reinforcing Amgen's and industry leadership.

What We Expect Of You

Basic Qualifications:

• Doctorate degree and at least 2 years of related research and scientific experience OR
• Master's degree and at least 6 years of related research and scientific experience OR
• Bachelor’s degree and 8 years of data sciences and scientific experience OR
• Associate’s degree and 10 years of data sciences and scientific experience OR
• High school diploma / GED and 12 years of data sciences and scientific experience

Preferred Qualifications:

• Doctorate in Epidemiology or a related field with significant observational research content.
• Experience in designing, executing, and analyzing observational research studies in the pharmaceutical or public health sector.
• Proficiency in applying causal inference frameworks (e.g., target trial emulation, causal roadmap) for real-world evidence generation.
• Experience in research supporting drug development.
• Experience with secondary data systems (e.g., administrative claims, EMR, registries).
• Experience in observational research project planning and management.
• Excellent verbal and written communication and interpersonal skills.
• Experience working in multi-disciplinary teams.

What you can expect from us

Amgen supports your professional and personal growth and well-being through competitive benefits and a collaborative culture. Our Total Rewards Plan includes health and welfare plans, financial plans for retirement savings, work/life balance initiatives, and career development opportunities. This may include a comprehensive employee benefits package (Retirement and Savings Plan with generous company contributions, group medical, dental, vision, life/disability insurance, flexible spending accounts), a discretionary annual bonus program, stock-based long-term incentives, award-winning time-off plans, and flexible work models (remote/hybrid).

Key skills/competency

Observational Research Senior Manager (Pharmacovigilance Epidemiology, Causal Inference, Obesity)

• Observational Research
• Pharmacovigilance
• Epidemiology
• Causal Inference
• Obesity Therapeutic Area
• Real-World Evidence (RWE)
• Drug Development
• Data Science
• Health Economics
• Biostatistics