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Legend Biotech US

Principal Engineer, Lentivirus Downstream Process Development

Legend Biotech US · Somerset, New Jersey, United States

Posted 22 days ago

or apply directly on Legend Biotech US's site. We never take the application ourselves.

Is this posting real?

This role has been open
22 days
Legend Biotech US's roles stay open a median of 40 days
Reposted
No
Salary listed
No
0% of Legend Biotech US's roles list one
Ghost-job risk at Legend Biotech US
high
36 stale, 2 reposted of 79 open
Hiring momentum
125 roles opened in the last 90 days
↑ up vs. the prior 90 days
Last confirmed on the employer's board
2026-09-17

Measured from postings appearing on and disappearing from Legend Biotech US's own greenhouse board since 2026-08-03. Full hiring picture for Legend Biotech US.

About this role

The Principal Engineer in Lentivirus Downstream Process Development will lead the design, optimization, and scaling of purification processes for lentiviral vectors. This role involves applying engineering principles, data analytics, and advanced modeling to enhance process efficiency and ensure compliance with GMP manufacturing standards. The engineer will collaborate with various teams to translate bench-scale processes to GMP production and guide a team of scientists in project execution.

Our read on this posting3.4out of 5
benefits
3/5
freshness
4/5
career value
5/5
role clarity
5/5
pay transparency
0/5

Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Legend Biotech US as an employer.

What you need

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, bioprocessing engineering or a related field
  • 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting
  • Strong engineering knowledge of bioprocessing modeling/simulation and the interaction of biomolecules, materials and machinery
  • Experience with modeling software and programming languages such as Python and MATLAB
  • Deep technical experience in purification, chromatography, and TFF
  • Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase and late phase clinical trials

Nice to have

  • Preferred experience in developing vector processes tailored for in vivo CAR-T generation and systemic delivery
  • Preferred experience in large scale (>50L) purification process
  • Language(s): Mandarin is a plus

What you get

  • Medical, dental, and vision insurance
  • 401(k) retirement plan with a company match that vests fully on day one
  • Eight (8) weeks of paid parental leave after just three (3) months of employment
  • Paid time off policy including vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
  • Voluntary benefits including flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
  • Voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs

Worth weighing

  • No salary listed in the posting, but a pay range is provided
  • Role involves significant responsibility and leadership, which may lead to high expectations
  • The position requires deep technical knowledge in a specialized field, which may limit candidates without specific experience

Summarised from Legend Biotech US's posting. Read the full original.

Listed by Legend Biotech US on their greenhouse job board, last confirmed open on 2026-09-17. PitchMeAI is not the employer.

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