Principal Scientist, Oligonucleotide (PMO, ASO) Development
Dyne Therapeutics · Waltham, MA
Posted 20 days ago
or apply directly on Dyne Therapeutics's site. We never take the application ourselves.
Is this posting real?
- This role has been open
- 20 days Dyne Therapeutics's roles stay open a median of 45 days
- Reposted
- No
- Salary listed
- No 0% of Dyne Therapeutics's roles list one
- Ghost-job risk at Dyne Therapeutics
- high 58 stale, 1 reposted of 69 open
- Hiring momentum
- 88 roles opened in the last 90 days ↑ up vs. the prior 90 days
- Last confirmed on the employer's board
- 2026-09-17
Measured from postings appearing on and disappearing from Dyne Therapeutics's own greenhouse board since 2026-08-03. Full hiring picture for Dyne Therapeutics.
About this role
The Principal Scientist of Oligonucleotide Development at Dyne Therapeutics will lead the strategy for chemical synthesis of PMO and modified ASO molecules, overseeing both internal execution and collaboration with CDMOs. This role involves driving process excellence, defining analytical strategies, and contributing to regulatory submissions while ensuring robust and scalable manufacturing processes. The position requires a strong presence on-site in Waltham, MA, 4-5 days a week.
- benefits
- 1/5
- freshness
- 4/5
- career value
- 4/5
- role clarity
- 5/5
- pay transparency
- 0/5
Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Dyne Therapeutics as an employer.
What you need
- Bachelor’s degree in Biochemistry, Chemical Engineering, Chemistry, or Pharmaceutical Sciences
- 8+ years of relevant pharmaceutical/biotech industry experience
- Proven track record in the process chemistry and development of PMO and modified ASO oligonucleotides
- Direct experience in the oversight of CDMOs
- Technical proficiency in analytical development, including impurity control strategies
- Exceptional interpersonal and communication skills
Nice to have
- Advanced degree preferred
- Experience in Research & Development preferably in a clinical-stage biotechnology company
Worth weighing
- On-site presence required 4-5 days a week, no remote work option
- Role involves significant regulatory responsibilities, which may be high-pressure
- Salary range provided is broad and may vary based on individual qualifications
Summarised from Dyne Therapeutics's posting. Read the full original.
Listed by Dyne Therapeutics on their greenhouse job board, last confirmed open on 2026-09-17. PitchMeAI is not the employer.
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