Principal Machine Learning Scientist
Adaptive Biotechnologies · Remote (WFH)
Posted about 3 months ago · $183,400 - $275,000
or apply directly on Adaptive Biotechnologies's site. We never take the application ourselves.
Is this posting real?
- This role has been open
- 80 days Adaptive Biotechnologies's roles stay open a median of 72 days
- Reposted
- No
- Salary listed
- Yes 96% of Adaptive Biotechnologies's roles list one
- Ghost-job risk at Adaptive Biotechnologies
- high 23 stale, 0 reposted of 25 open
- Hiring momentum
- 33 roles opened in the last 90 days ↑ up vs. the prior 90 days
- Last confirmed on the employer's board
- 2026-10-22
Measured from postings appearing on and disappearing from Adaptive Biotechnologies's own greenhouse board since 2026-08-03. Full hiring picture for Adaptive Biotechnologies.
About this role
The Senior or Principal Machine Learning Scientist at Adaptive Biotechnologies will develop deep learning models for predicting TCR-pMHC specificity, collaborating with various scientific teams. The role involves integrating large biological datasets, designing and evaluating models, and translating biological principles into modeling strategies. Senior-level responsibilities include ownership of modeling workstreams, while Principal-level responsibilities expand to technical leadership and strategic direction across teams.
- benefits
- 2/5
- freshness
- 1/5
- career value
- 5/5
- role clarity
- 5/5
- pay transparency
- 5/5
Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Adaptive Biotechnologies as an employer.
What you need
- PhD in a quantitative discipline such as Machine Learning, Computational Biology, Computer Science, or a related field, or an equivalent combination of education and experience
- Progressive experience developing and deploying deep learning methods for scientific, biological, or similarly complex real-world problems
- Strong hands-on experience with Python and modern machine learning tooling; PyTorch preferred
- Strong experience with deep learning architecture design and implementation
- Experience working with large datasets and high-performance computing environments
- Ability to independently define, scope, and execute complex technical research problems
Nice to have
- Strong experience with protein structure prediction or analysis
- Experience in one or more of the following areas: Protein-protein interaction modeling, Protein design or generative modeling, Protein language models or large-scale foundation models, Molecular dynamics or free energy perturbation methods, Large-scale biological datasets, Immunology and immune receptor specificity, including antibody or TCR specificity
- Publications, conference papers, patents, or delivered products demonstrating applied machine learning impact in biological problems
What you get
- Senior Machine Learning Scientist salary range: $144,600 - $217,000
- Principal Machine Learning Scientist salary range: $183,400 - $275,000
- Equity grant
- Bonus eligibility
Worth weighing
- No specific mention of remote work flexibility beyond the stated remote location
- No information on additional benefits or perks beyond compensation
- Adaptive is not currently sponsoring candidates requiring work authorization support for this position
Summarised from Adaptive Biotechnologies's posting. Read the full original.
Listed by Adaptive Biotechnologies on their greenhouse job board, last confirmed open on 2026-10-22. PitchMeAI is not the employer.
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