Senior Technical Program Manager, Productivity Engineering (Data Platform · AI Transformation)
10x Genomics · Pleasanton, California, USA HQ
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- Pleasanton, California, USA HQ
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Subject: Interested in the Senior Technical Program Manager, Productivity Engineering (Data Platform · AI Transformation) role at 10x Genomics
Hi Avery — I came across the Senior Technical Program Manager, Productivity Engineering (Data Platform · AI Transformation) opening and wanted to reach out directly. I've spent the last few years doing exactly this kind of work, and 10x Genomics stood out because…
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About the role
About the Role
10x Genomics is rewriting the rules of biological discovery — and our platform needs to move as fast as our science. We are building a modern, AI-first technology stack, and this role sits at the center of it.
We are looking for a Senior TPM who thrives in ambiguity, builds the plan rather than inherits one, and understands that data programs are not just delivery work — they are the foundation that makes AI possible. You will own the roadmap across our AI / Data Platform and integration programs, and you will expand your scope as the org scales.
You have operated in environments where the process did not exist yet — and you built it. You do not wait for a fully-defined charter. You are energized by a flat org, a direct reporting line to leadership, and the expectation that you own outcomes end-to-end.
What You Will Own
Program Ownership & Delivery
- Own and drive the roadmap across AI / Data Platform and Finance integration programs; expand scope as the business grows.
- Take programs from zero to shipped — scoping, sequencing, dependency management, risk visibility, and retrospective.
- Translate ambiguous business problems into structured, time-bound programs with clear milestones and decision points.
- Run delivery end-to-end without needing a playbook handed to you. You write the playbook.
- Hold engineering, product, and business teams accountable to commitments — without relying on hierarchy to do it.
AI-First Thinking
- Understand how Data Platform programs create upstream capability for AI and ML — design with that lens from day one.
- Own AI-specific program tracks: NLQ rollout, Bedrock integrations, model deployment pipelines, and data readiness for AI.
- Partner with Data Engineering, Product, and Science teams to ensure programs are not just delivered but compound into AI readiness.
- Push teams to think end-to-end: what does this program unlock downstream, and are we building toward that?
- Represent the AI program portfolio to senior leadership with clarity on status, risks, and strategic trajectory.
Finance & Application Integrations
- Own delivery of modernized integration programs — ensuring cross-application flows (ERP, CRM, supply chain) work reliably on a modern tech stack.
- Drive the retirement of fragile legacy middleware and the adoption of event-driven, scalable integration patterns.
- Partner with Finance, Operations, and Engineering to translate business process requirements into well-architected integration programs.
- Ensure tax, order management, procurement, and revenue-impacting workflows have zero-tolerance reliability standards.
- Define the integration roadmap in partnership with architects and engineering leads — own it, defend it, and ship it.
Leadership & Communication
- Operate effectively in a flat org: influence without hierarchy, build alignment without bureaucracy.
- Be the connective tissue across Engineering, Product, Finance, and Operations — translate technical complexity into business impact.
- Identify cross-program risks before they become incidents. Escalate with a proposed solution, not just a flag.
Minimum Requirements
- 5+ years of TPM experience with demonstrated ownership of complex, multi-stakeholder programs.
- Meaningful time at a mid-stage startup (Series A–D), or equivalent experience as a founder or early employee — you know what it means to build without a safety net.
- Hands-on delivery across data infrastructure or data platform programs: pipelines, warehousing, ELT, real-time data flows.
- Fluency in modern integration patterns — you can hold a substantive conversation with engineers about event-driven architecture, API design, and middleware retirement without needing a glossary.
- Proven ability to build the roadmap, not inherit one. You have done this before and have the scars to show it.
- Strong written and verbal communication — you can write a crisp exec update and a detailed program brief and know when each is appropriate.
Preferred Skills and Experience
- Experience driving AI or ML programs: NLQ, model deployment pipelines, feature stores, or GenAI product integrations.
- Familiarity with the 10x stack or equivalent: Snowflake, Airflow, Kafka, dbt, AWS, Oracle Fusion.
- Background in life sciences, genomics, or regulated data environments.
- Worked cross-functionally across Engineering, Product, Finance, and Operations simultaneously — not sequentially.
Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company’s total compensation package.
About 10x Genomics
At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.
We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.
Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.
Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.
10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.
Please be aware of recruitment scams impersonating 10x Genomics. All recruiting communication will come from email addresses @10xgenomics.com. We also want to encourage you to apply to 10x Genomics positions directly on our careers site, Careers.10xgenomics.com or from reputable third party sites, such as LinkedIn or Indeed. We will never request payment or sensitive personal information during the recruiting process.
