Principal Scientist, LNP Platform & Process Development
Tr1X · San Diego, CA
Posted 19 days ago · $169,000 - $185,000
or apply directly on Tr1X's site. We never take the application ourselves.
Is this posting real?
- This role has been open
- 19 days Tr1X's roles stay open a median of 19 days
- Reposted
- No
- Salary listed
- Yes 100% of Tr1X's roles list one
- Ghost-job risk at Tr1X
- moderate 1 stale, 0 reposted of 4 open
- Hiring momentum
- 4 roles opened in the last 90 days ↑ up vs. the prior 90 days
- Last confirmed on the employer's board
- 2026-09-17
Measured from postings appearing on and disappearing from Tr1X's own greenhouse board since 2026-08-03. Full hiring picture for Tr1X.
About this role
The Principal Scientist, LNP Platform & Process Development at Tr1X will lead the design and optimization of lipid nanoparticle (LNP) formulations for mRNA delivery, playing a crucial role in the development of the company's CAR-Treg platform. This hands-on position involves evaluating lipid compositions, developing production processes, and collaborating with biology teams to support in vitro and in vivo studies, all while contributing to IND-enabling documentation and long-term strategy for LNP platform development.
- benefits
- 4/5
- freshness
- 4/5
- career value
- 4/5
- role clarity
- 5/5
- pay transparency
- 5/5
Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Tr1X as an employer.
What you need
- Ph.D. in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, or a related field with a minimum of 6 years of relevant industry experience; or M.S. with 10+ years; or B.S. with 12+ years
- Demonstrated in-depth expertise in LNP formulation and process development
- Hands-on experience with microfluidic or scalable mixing technologies and downstream purification strategies such as TFF
- Strong experience with analytical characterization of tLNP systems and application of statistical design tools for process optimization
- Experience with mRNA therapeutics or nucleic acid delivery systems
- Experience with conjugation of targeting ligands to lipid nanoparticles
Nice to have
- Prior exposure to immunotherapy or in-vivo cell therapy platforms
- Experience correlating formulation attributes with in vivo performance (mouse, NHP)
- Experience with mRNA production and analytical quality control
What you get
- Base salary
- Discretionary annual target bonus
- Incentive stock options
- 401(k) retirement plan with company contribution
- Health and welfare insurance plans including medical, dental, vision, long-term and short-term disability, and life insurance
- Paid time off (PTO)
Worth weighing
- Position is on-site in San Diego, which may limit remote work options
- Travel may be required up to 10% of the time
- No specific mention of career advancement opportunities or professional development programs
Summarised from Tr1X's posting. Read the full original.
Listed by Tr1X on their greenhouse job board, last confirmed open on 2026-09-17. PitchMeAI is not the employer.
More roles at Tr1X
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