Scientist II - Sr. Scientist, CRISPR Specificity & Genomic Safety
Profluent · Emeryville, California, United States; On-site
Posted about 2 months ago
or apply directly on Profluent's site. We never take the application ourselves.
Is this posting real?
- This role has been open
- 63 days Profluent's roles stay open a median of 63 days
- Reposted
- No
- Salary listed
- No 0% of Profluent's roles list one
- Ghost-job risk at Profluent
- high 12 stale, 0 reposted of 12 open
- Hiring momentum
- 17 roles opened in the last 90 days ↑ up vs. the prior 90 days
- Last confirmed on the employer's board
- 2026-10-05
Measured from postings appearing on and disappearing from Profluent's own greenhouse board since 2026-08-03. Full hiring picture for Profluent.
About this role
Profluent is looking for a Scientist II - Sr. Scientist to develop and implement workflows for assessing the specificity and safety of their CRISPR base editing platform. The role involves establishing base-editor specificity workflows, collaborating with various teams to generate datasets, and mentoring junior scientists. The candidate will also be responsible for interpreting data, optimizing methods, and ensuring reproducibility in experimental processes.
- benefits
- 3/5
- freshness
- 1/5
- career value
- 5/5
- role clarity
- 5/5
- pay transparency
- 0/5
Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Profluent as an employer.
What you need
- PhD (or equivalent) in molecular biology, genomics, genome editing, biochemistry, bioengineering, genetics, chemical biology, or a related field
- 2-4 years of relevant industry experience in genome editing specificity and genomic safety assessment
- Deep expertise and hands-on experience with CRISPR-based genome editing systems, particularly base editors
- Hands-on experience developing, optimizing, or applying NGS-based workflows for genome editing analysis
- Strong experimental background in molecular biology, mammalian cell culture, genome editing reagent delivery, NGS library preparation, assay troubleshooting, and quantitative analysis of editing outcomes
- Experience interpreting complex sequencing datasets and collaborating with bioinformatics or computational biology teams
Nice to have
- Experience with therapeutic genome editing programs and genomic safety packages for candidate nomination, IND-enabling studies, or regulatory-facing documentation
- Experience working with disease-relevant primary cells, ex vivo edited cells, iPSC-derived systems, or other therapeutically relevant model systems
- Familiarity with ML-guided enzyme engineering campaigns
- Expertise in protein purification of genome editors for use in biochemical off-target assays
What you get
- High-growth opportunity with meaningful impact on the future of protein design
- Competitive compensation package with equity participation
- 401(k) with a strong employer match
- Comprehensive benefits including health/dental/vision insurance
- Generous PTO policy and commitment to work-life balance
- Professional development opportunities in a cutting-edge field at the intersection of AI and biology
Worth weighing
- On-site position in Emeryville, California
- No salary listed in the benefits section, but a hiring salary range is provided
- Requires ongoing work authorization in the United States without employer sponsorship
Summarised from Profluent's posting. Read the full original.
Listed by Profluent on their greenhouse job board, last confirmed open on 2026-10-05. PitchMeAI is not the employer.
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