Executive Director / Vice President, Biology & Translational Pharmacology
Profluent · Emeryville, California, United States; On-site
Posted about 2 months ago
or apply directly on Profluent's site. We never take the application ourselves.
Is this posting real?
- This role has been open
- 63 days Profluent's roles stay open a median of 63 days
- Reposted
- No
- Salary listed
- No 0% of Profluent's roles list one
- Ghost-job risk at Profluent
- high 12 stale, 0 reposted of 12 open
- Hiring momentum
- 17 roles opened in the last 90 days ↑ up vs. the prior 90 days
- Last confirmed on the employer's board
- 2026-10-05
Measured from postings appearing on and disappearing from Profluent's own greenhouse board since 2026-08-03. Full hiring picture for Profluent.
About this role
Profluent is looking for an Executive Director / Vice President to lead the scientific strategy for their gene editing therapeutic portfolio, focusing on liver-directed customized base editing for severe inborn metabolic diseases. The role involves overseeing translational biology and in vivo pharmacology, managing cross-functional therapeutic programs, and collaborating with various teams to generate data packages for development candidates. The ideal candidate will have extensive experience in genetic medicines and a strong understanding of liver biology and metabolic diseases.
- benefits
- 3/5
- freshness
- 1/5
- career value
- 5/5
- role clarity
- 5/5
- pay transparency
- 0/5
Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Profluent as an employer.
What you need
- PhD, MD, DVM, PharmD, or equivalent advanced degree in pharmacology, molecular biology, genetics, physiology, hepatology, bioengineering, medicine, or a related discipline
- 12+ years of biopharma R&D experience with a strong track record in genetic medicines, liver biology, translational pharmacology, and preclinical development
- Demonstrated track record advancing multiple therapeutic programs from concept through development candidate nomination
- Deep understanding of liver biology and metabolic disease
- Experience designing and interpreting in vivo pharmacology studies
- Demonstrated ability to lead multidisciplinary scientific teams
Nice to have
- Direct experience with genome editing is valuable but not required
- Experience advancing at least one program into IND-enabling studies or clinical development is strongly preferred
- Extensive experience with rare liver diseases, lipid biology, hepatology, fibrosis biology, and/or metabolic liver disease
- Working knowledge of IND-enabling requirements, toxicology interfaces, CMC considerations, bioanalytical assay needs, and regulatory expectations
- Direct experience or at least high-level familiarity with gene editing proteins such as nucleases, base editors, prime editors, recombinases
What you get
- High-growth opportunity with meaningful impact on the future of protein design
- Competitive compensation package with equity participation
- 401(k) with a strong employer match
- Comprehensive benefits including health/dental/vision insurance
- Generous PTO policy and commitment to work-life balance
- Professional development opportunities in a cutting-edge field at the intersection of AI and biology
Worth weighing
- No remote work options mentioned, position is on-site
- High level of responsibility and leadership required
- Candidates must have ongoing work authorization in the United States that does not require employer sponsorship
Summarised from Profluent's posting. Read the full original.
Listed by Profluent on their greenhouse job board, last confirmed open on 2026-10-05. PitchMeAI is not the employer.
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