Sr. Principal Scientist / Director, DMPK & Bioanalytical Sciences
Alltrna · Cambridge, Massachusetts, United States
Posted about 3 months ago · $179,000 - $236,000
or apply directly on Alltrna's site. We never take the application ourselves.
Is this posting real?
- This role has been open
- 82 days Alltrna's roles stay open a median of 83 days
- Reposted
- No
- Salary listed
- Yes 100% of Alltrna's roles list one
- Ghost-job risk at Alltrna
- high 3 stale, 1 reposted of 3 open
- Hiring momentum
- 3 roles opened in the last 90 days ↑ up vs. the prior 90 days
- Last confirmed on the employer's board
- 2026-10-25
Measured from postings appearing on and disappearing from Alltrna's own greenhouse board since 2026-08-03. Full hiring picture for Alltrna.
About this role
The Principal/Senior Principal Scientist in DMPK will lead the DMPK strategy and oversee bioanalytical work for both nonclinical and clinical programs. This role involves designing and analyzing PK and PK-PD studies, managing CRO partnerships, and contributing to regulatory filings. The ideal candidate will have extensive experience in DMPK, strong leadership skills, and the ability to thrive in a fast-paced biotech environment.
- benefits
- 2/5
- freshness
- 1/5
- career value
- 4/5
- role clarity
- 4/5
- pay transparency
- 5/5
Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Alltrna as an employer.
What you need
- PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, or related field
- 8+ years of industry experience in DMPK or a closely related function
- Working knowledge of bioanalytical methods (e.g., LC-MS/MS, ligand binding assays, NGS)
- Demonstrated CRO oversight - vendor qualification, study monitoring, data review
- Experience designing and overseeing in vivo nonclinical PK and PK-PD studies for novel delivery modalities
- Hands-on experience with PK and PK-PD data analysis and associated software (e.g., Phoenix WinNonlin)
Nice to have
- Experience in rare disease or genetic medicine
- Experience with RNA-based therapies
- Familiarity with LNP platform biology and delivery landscape
- Familiarity with GLP toxicology study design and ICH nonclinical guidelines
- Experience operating in a cross-functional leadership role at a clinical-stage biotech
What you get
- Healthcare coverage
- Annual incentive program
- Retirement benefits
- Broad range of other benefits
Worth weighing
- No specific mention of remote work options
- Salary range provided but may be modified in the future
- Fast-paced environment may imply high expectations and workload
Summarised from Alltrna's posting. Read the full original.
Listed by Alltrna on their greenhouse job board, last confirmed open on 2026-10-25. PitchMeAI is not the employer.
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