Key Account Manager
Arrowhead Pharmaceuticals · Dallas, Texas, United States
- Hybrid
- Full-time
- $200,000 / year
- Dallas, Texas, United States
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Subject: Interested in the Key Account Manager role at Arrowhead Pharmaceuticals
Hi Avery — I came across the Key Account Manager opening and wanted to reach out directly. I've spent the last few years doing exactly this kind of work, and Arrowhead Pharmaceuticals stood out because…
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Job highlights
- Lead enterprise engagement with health systems.
- Drive adoption of cardiometabolic portfolio.
- Build trusted relationships with stakeholders.
- Develop clinical fluency in rare diseases.
- Achieve account performance targets.
About the role
About Arrowhead Pharmaceuticals
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enable us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are agile, science-driven innovators who collaborate to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking a strategically minded, relationship-driven Key Account Manager (KAM) to lead enterprise engagement across priority health systems, Integrated Delivery Networks (IDNs), and complex accounts within an assigned geography. This role is central to building durable institutional access and driving adoption of Arrowhead's cardiometabolic portfolio, including Plozasiran for rare cardiovascular conditions such as Familial Chylomicronemia Syndrome (FCS).
The Key Account Manager will operate at the intersection of clinical science, health system navigation, and commercial execution. This individual will establish Arrowhead as a trusted partner to health systems by embedding Plozasiran into clinical pathways, supporting formulary access, and ensuring seamless coordination between system-level strategy and field prescriber activation.
Responsibilities
Enterprise Account Strategy & Execution
- Develop and execute comprehensive account strategies across priority IDNs, health systems, and complex accounts within an assigned geography.
- Build institutional access through formulary engagement, protocol development, and clinical pathway integration.
- Drive integration of Plozasiran into treatment algorithms, order sets and clinical workflows in partnership with key institutional decision-makers.
- Own multi-year account growth plans, including system-level partnership development, opportunity sizing, and sustained execution against account objectives.
- Use adoption, access, and performance data to segment and prioritize accounts, shape engagement strategy, and identify the highest-impact opportunities and barriers.
- Monitor account-level adoption metrics and proactively address access barriers to accelerate pull-through.
- Maintain rigorous account planning discipline, including regular business reviews and updated stakeholder maps.
Stakeholder Engagement & Relationship Development
- Build and maintain trusted relationships with a broad set of institutional stakeholders, including pharmacy leadership, population health leaders, value analysis committees, and clinical champions.
- Engage compliantly in value-based discussions, including health economic, outcomes, and real-world evidence conversations tailored to institutional priorities.
- Ensure alignment between enterprise decision-makers and field-level prescriber activation efforts.
- Navigate multi-layered institutional approval processes with strategic agility and appropriate urgency.
Clinical Science & Patient Identification
- Develop deep clinical fluency in FCS, ApoC-III biology, and the mechanism and evidence base for Plozasiran.
- Educate institutional stakeholders on disease prevalence, diagnostic pathways, and the patient identification opportunity within their system.
- Collaborate with Health IT initiatives to support patient identification tools and clinical workflow integration.
- Serve as a credible clinical and commercial resource within accounts, reinforcing Arrowhead’s scientific leadership.
Cross-Functional Collaboration & Alignment
- Partner closely with Rare Disease Specialists and Regional Sales Directors to coordinate and align account strategy with field execution.
- Collaborate with Market Access, Marketing, Medical Affairs, and Commercial Operations to remove systemic barriers and align institutional messaging.
- Provide timely and actionable field insights regarding competitive dynamics, formulary positioning, and access trends to regional and national leadership.
- Participate constructively in cross-functional planning meetings, commercial launches, and strategic initiatives.
Business Performance & Compliance Accountability
- Own account-level performance targets and adoption objectives within assigned geography.
- Maintain and proactively monitor forecast accuracy and account-level growth indicators.
- Drive disciplined CRM documentation and reporting standards to support territory and business analytics.
- Conduct all enterprise engagements in full compliance with applicable laws, regulations, and Arrowhead's ethical standards.
Travel & Engagement
- Field-based travel required (~60%), including health system meetings, executive engagements, and regional commercial initiatives.
- Participation in regional and national commercial meetings, training programs, and launch initiatives.
Experience
- Minimum 5+ years of pharmaceutical or biotech experience required.
- Experience in IDN, health system, or complex account management required.
- Demonstrated ability to navigate and influence formulary, protocol, or pathway decisions within complex institutional environments.
- Track record of consistent performance and territory growth in a field-based commercial role.
- Experience in specialty, rare disease, or cardiometabolic therapeutic areas preferred.
Skills & Competencies
- Strong executive presence with the ability to engage senior institutional and clinical stakeholders.
- Advanced account management and enterprise planning skills.
- Solid understanding of health system economics, reimbursement dynamics, and institutional access pathways.
- Ability to translate complex clinical and health economic data into compelling, audience-appropriate value narratives.
- Strong analytical and business acumen with a data-driven approach to prioritization and decision-making.
- High level of resilience, adaptability, and sound judgment in dynamic and ambiguous environments.
- Collaborative mindset with the ability to work effectively across functions, geographies, and organizational levels.
- Exceptional communication, negotiation, and stakeholder navigation skills.
Compensation & Benefits
- Competitive base salary: $190,000 - $210,000 plus incentive compensation.
- Equity (RSUs) eligibility and car allowance program.
- Comprehensive benefits package including health, dental, vision, and 401(k).
Key skills/competency
- Key Account Management
- Health System Navigation
- Formulary Access
- Clinical Pathway Integration
- Stakeholder Engagement
- Value-Based Discussions
- Rare Disease Therapeutics
- Cardiometabolic Portfolio
- Commercial Execution
- Relationship Management
Skills & topics
- Key Account Manager
- Pharmaceutical Sales
- Biotechnology
- Health System Engagement
- Formulary Access
- Rare Disease
- Cardiometabolic
- RNAi
- Pasadena
- California
How to get hired
- Tailor your resume: Highlight your 5+ years of pharma/biotech experience, focusing on IDN, health system, or complex account management, and any rare disease or cardiometabolic experience.
- Showcase your skills: Emphasize your ability to navigate formulary decisions, develop enterprise account strategies, and build relationships with senior stakeholders.
- Quantify achievements: Use data to demonstrate a track record of consistent performance and territory growth in previous commercial roles.
- Prepare for interviews: Be ready to discuss your approach to value-based discussions, clinical science fluency, and cross-functional collaboration.
Technical preparation
Behavioral questions
Frequently asked questions
- What is Arrowhead Pharmaceuticals seeking in a Key Account Manager?
- Arrowhead Pharmaceuticals is seeking a Key Account Manager (KAM) with strategic thinking and relationship-building skills to lead engagement with priority health systems and IDNs. The KAM will focus on institutional access and driving adoption of their cardiometabolic portfolio, particularly Plozasiran for rare cardiovascular conditions.
- What therapeutic areas are prioritized for this Key Account Manager role?
- This Key Account Manager role is focused on Arrowhead's cardiometabolic portfolio, with a specific mention of Plozasiran for rare cardiovascular conditions like Familial Chylomicronemia Syndrome (FCS). Experience in specialty, rare disease, or cardiometabolic therapeutic areas is preferred.
- What are the key responsibilities of the Key Account Manager at Arrowhead Pharmaceuticals?
- Key responsibilities include developing and executing enterprise account strategies, building institutional access through formulary engagement and pathway integration, fostering trusted relationships with stakeholders, developing clinical fluency in relevant diseases, collaborating cross-functionally, and achieving account-level performance targets.
- What kind of experience is required for the Key Account Manager position?
- A minimum of 5 years of pharmaceutical or biotech experience is required, with a strong emphasis on IDN, health system, or complex account management. Demonstrated ability to influence formulary and pathway decisions, along with a track record of consistent performance, is essential.
- What is the expected travel for the Key Account Manager role?
- The Key Account Manager role requires significant field-based travel, approximately 60% of the time. This includes travel for health system meetings, executive engagements, regional commercial initiatives, and participation in national meetings and training programs.
- How does Arrowhead Pharmaceuticals approach innovation and patient care?
- Arrowhead Pharmaceuticals is dedicated to developing medicines that treat intractable diseases by silencing the genes that cause them. They leverage a broad portfolio of RNA chemistries and delivery modes to induce durable knockdown of target genes, aiming to address conditions not otherwise treatable.
- What is the compensation and benefits package for the Key Account Manager role?
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