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Flagship Pioneering, Inc.

Director/Senior Director, Computational Chemistry

Flagship Pioneering, Inc. · Cambridge, MA USA

Posted 29 days ago · $176,000 - $294,300

or apply directly on Flagship Pioneering, Inc.'s site. We never take the application ourselves.

Is this posting real?

This role has been open
29 days
Flagship Pioneering, Inc.'s roles stay open a median of 45 days
Reposted
No
Salary listed
Yes
89% of Flagship Pioneering, Inc.'s roles list one
Ghost-job risk at Flagship Pioneering, Inc.
high
50 stale, 1 reposted of 100 open
Hiring momentum
144 roles opened in the last 90 days
↑ up vs. the prior 90 days
Last confirmed on the employer's board
2026-09-17

Measured from postings appearing on and disappearing from Flagship Pioneering, Inc.'s own greenhouse board since 2026-08-03. Full hiring picture for Flagship Pioneering, Inc..

About this role

The Director/Senior Director of Computational Chemistry at Flagship Labs 111 Inc. will lead the design and optimization of heterobifunctional small molecules, collaborating with various teams to integrate computational tools into the drug discovery process. This role involves defining strategic visions, overseeing cheminformatics strategies, evaluating molecular properties, and advancing computational modeling capabilities. The successful candidate will also mentor scientists and represent the computational chemistry function in leadership discussions.

Our read on this posting4.0out of 5
benefits
2/5
freshness
4/5
career value
4/5
role clarity
5/5
pay transparency
5/5

Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Flagship Pioneering, Inc. as an employer.

What you need

  • PhD in Chemistry, Medicinal Chemistry, Computational Chemistry, or a related discipline
  • 10+ years of relevant industry experience
  • Demonstrated scientific leadership and people management experience
  • Deep expertise in computational medicinal chemistry and structure-based drug design
  • Ability to drive and evaluate synthetically actionable molecular designs
  • Experience using cheminformatics tools for compound design, analysis and prioritization

Nice to have

  • Prior experience working on heterobifunctional small molecules (e.g., PROTACs)
  • Familiarity with ADME optimization challenges for large, flexible molecules
  • Prior experience in an early-stage or startup biotech environment

What you get

  • Healthcare coverage
  • Annual incentive program
  • Retirement benefits
  • Broad range of other benefits

Worth weighing

  • No specific mention of remote work options
  • Role involves significant leadership responsibilities which may require extensive collaboration
  • Salary range provided but compensation depends on various factors

Summarised from Flagship Pioneering, Inc.'s posting. Read the full original.

Listed by Flagship Pioneering, Inc. on their greenhouse job board, last confirmed open on 2026-09-17. PitchMeAI is not the employer.

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