or apply directly on Calico 's site. We never take the application ourselves.
Is this posting real?
- This role has been open
- 8 days Calico 's roles stay open a median of 55 days
- Reposted
- No
- Salary listed
- Yes 83% of Calico 's roles list one
- Ghost-job risk at Calico
- high 15 stale, 2 reposted of 18 open
- Hiring momentum
- 23 roles opened in the last 90 days ↑ up vs. the prior 90 days
- Last confirmed on the employer's board
- 2026-09-27
Measured from postings appearing on and disappearing from Calico 's own greenhouse board since 2026-08-03. Full hiring picture for Calico .
About this role
The Principal Scientist, DMPK at Calico will lead the development and implementation of DMPK strategies to support drug discovery and development. This role involves collaborating with project teams and external partners, managing CRO relationships, and conducting DMPK studies. The scientist will also analyze data, author reports, and stay updated on advancements in DMPK science.
- benefits
- 1/5
- freshness
- 5/5
- career value
- 4/5
- role clarity
- 5/5
- pay transparency
- 5/5
Scored from the posting itself — how clearly the role is described, how much it says about pay and benefits, and how recently it was listed. Not a judgement of Calico as an employer.
What you need
- Ph.D. in pharmacokinetics, drug metabolism, or a related field
- 8+ years of experience in DMPK within the pharmaceutical or biotechnology industry
- Experience as a DMPK functional representative on drug discovery teams
- Strong understanding of DMPK principles and their application to drug discovery and development
- Extensive experience in designing and conducting in vitro and in vivo DMPK studies
- Proven ability to analyze and interpret DMPK data to inform drug development decisions
Nice to have
- Experience with a variety of therapeutic modalities, including small molecules, biologics, and peptides
- Familiarity with regulatory guidelines and requirements for DMPK studies
- Prior experience in writing regulatory documents is highly desirable
- Experience with modeling and simulation software such as Phoenix WinNonlin, Gastroplus, SimCYP
What you get
- Estimated base salary range of $197,000 - $235,000
- Eligible for two annual cash bonuses
Worth weighing
- Onsite work required 5 days a week
- Role involves significant collaboration with external partners and CROs
- Focus on DMPK may limit exposure to other areas of drug discovery
Summarised from Calico 's posting. Read the full original.
Listed by Calico on their greenhouse job board, last confirmed open on 2026-09-27. PitchMeAI is not the employer.
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